Ammonia → 4-Butoxymethyl-benzylamine

Participants

Reaction Steps

To a mixture of LAH (80%, 600 mg) and THF (10 mL) were added 4-butoxymethyl-benzonitrile (600 mg) described in Manufacturing Example 43-1 and THF (10 mL) at 0° C., which was stirred for 4 hours at room temperature. A 28% aqueous ammonia solution was added by drops to the reaction mixture at 0° C., and the excess LAH was quenched. The temperature was raised to room temperature, and then filtration was performed. The solvent was evaporated from the filtrate under a reduced pressure to obtain of the titled compound (620 mg).

Provenance & Evidence