Carbon Tetrachloride → 1-Butoxymethyl-4-chloromethyl-benzene

Participants

Reaction Steps

A mixture of (4-butoxymethyl-phenyl)-methanol (190 mg) described in Manufacturing Example 43-3, triphenylphosphine (310 mg), and carbon tetrachloride (3 mL) was heated to reflux for 7 hours. The reaction mixture was cooled to room temperature, and then the solvent was evaporated under a reduced pressure. The residue was purified by neutral silica gel column chromatography (ethyl acetate:heptane=1:15) to obtain the titled compound (180 mg).

Provenance & Evidence