HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 2-PyridinaMine, 5-(1H-tetrazol-5-yl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 2-Amino-5-cyanopyridine | HCID 818260 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ammonia | HCID 222 | — |
| Product | 2-PyridinaMine, 5-(1H-tetrazol-5-yl)- | HCID 58772628 | 126.4% |
Reaction Steps
2-Amino-5-cyanopyridine (1.0 g), sodium azide (1.1 g), ammonium chloride (890 mg), and DMF (15 mL) were stirred for 2 hours and 15 minutes at 100° C. The reaction solution was directly purified by silica gel chromatography (ethyl acetate, then ethyl acetate:methanol:concentrated aqueous ammonia=6:2:1) to obtain the titled compound (860 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183264B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-98006bfa3bb84f6aa5ff7597352bc58e |
| Source note | uspto-grants-2012_05 |