HCID 135473043, compound → HCID 135925388, compound

HRID 1927282Notes

Reaction equation

HRID 1927282 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9](=[O:16])[NH:8][C:7]=12)#[N:2].[H][H]>N.CO.[Ni]>[NH2:2][CH2:1][C:3]1[CH:4]=[N:5][N:6]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9](=[O:16])[NH:8][C:7]=12

Participants

6

Reactant 2

HCID 135473043HCID 135473043, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 135925388HCID 135925388, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 222AmmoniaSolventHCID 887MethanolSolvent2×

Procedure

A suspension of 1.5 g of 3-cyano-4H-pyrazolo[1,5-a]quinazolin-5-one in 150 mL of 20% ammonia in methanol was shaken with 15 g of aqueous Raney nickel at ambient temperature under 60 psi of hydrogen for 70 minutes. The suspension was diluted with 150 mL of methanol and warmed to dissolve the precipitated product. Filtration through a nylon membrane and concentration of the filtrate yielded the title compound. MS (ESI) m/z 198 (M+H—NH3)+.

Workup

  1. temperaturewarmed
  2. dissolutionto dissolve the precipitated product
  3. filtrationFiltration through a nylon membrane and concentration of the filtrate

Sources & evidence

ORD record
ord-37ce4ab051f84be6a592ff5f5a2a6aab
Source dataset
uspto-grants-2012_05
Patent number
US08183250B2

Reaction notes

Loading…