HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1927290Generated: November 1, 2026
Water → Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate
https://huagongshe.com/reaction/1927290
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzoic acid, 2-hydrazinyl-, hydrochloride (1:1) | HCID 104169 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Ethyl 2-cyano-3-ethoxyacrylate | HCID 1715183 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate | HCID 136389266 | — |
Reaction Steps
A mixture of 2-hydrazinylbenzoic acid hydrochloride (1.05 g, 5.57 mmol), (E)-ethyl 2-cyano-3-ethoxyacrylate (0.9 g, 5.32 mmol) and sodium acetate (0.457 g, 5.57 mmol) in DMF (7 mL) was heated to 140° C. for 2 h then cooled. Water (5 mL) was added and the mixture was stirred at ambient temperature for 1 h then filtered. The solid was washed with H2O, EtOH and Et2O then dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08183250B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-c64623aae70b4548a6b0f3f527107b67 |
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| Source note | uspto-grants-2012_05 |
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