HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-(Ethoxymethylene)propanedinitrile | HCID 67152 | — |
| Reactant | Benzoic acid, 2-hydrazinyl-, hydrochloride (1:1) | HCID 104169 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate | HCID 136389266 | — |
Reaction Steps
A mixture of 2-hydrazinylbenzoic acid hydrochloride (10 g, 53 mmol), 2-(ethoxymethylene)malononitrile (6.5 g, 53.2 mmol) and sodium ethoxide (4.85 g, 257 mmol) in EtOH (100 mL) was refluxed overnight then cooled to ambient temperature. Water was added and the mixture was stirred at ambient temperature for 1 h then filtered. The solid was washed with H2O, EtOH and Et2O then dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183250B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-391fcd7d3502490dbc94dbabb9bbe8a3 |
| Source note | uspto-grants-2012_05 |