HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1927317Generated: October 25, 2026
Acetone Cyanohydrin → 2-Methyl-2-[(4-methylphenyl)amino]propanenitrile
https://huagongshe.com/reaction/1927317
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetone Cyanohydrin | HCID 6406 | — |
| Reactant | p-Toluidine | HCID 7813 | — |
| Product | 2-Methyl-2-[(4-methylphenyl)amino]propanenitrile | HCID 21239243 | 99% |
Reaction Steps
A mixture of p-toluidine (1.07 g, 10 mmol) and acetone cyanohydrin (10 ml) was heated to 80° C. and stirred for 4 h. The medium was concentrated and dried under vacuum to yield 2-methyl-2-(4-methylphenyl)aminopropanenitrile, 5a (1.72g, 9.9 mmol, 99%) as brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08183274B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-cbee33dd5865432d9668d4d0c9b07f3c |
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| Source note | uspto-grants-2012_05 |
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