HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1927319Generated: October 27, 2026
Triethylamine → 4-[3-(4-Methylphenyl)-5-imino-4,4-dimethyl-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile
https://huagongshe.com/reaction/1927319
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile | HCID 11615540 | — |
| Reactant | 2-Methyl-2-[(4-methylphenyl)amino]propanenitrile | HCID 21239243 | — |
| Reactant | Propan-2-one--dichloromethane (1/1) | HCID 21584124 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[3-(4-Methylphenyl)-5-imino-4,4-dimethyl-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile | HCID 15951818 | 17% |
Reaction Steps
Triethylamine (0.101 g, 1 mmol) was added to a solution of 1a (0.456 g, 2 mmol) and 5a (0.348 g, 2 mmol) in dry THF (3 ml). The reaction mixture was stirred at 0° C. for 2 days and then concentrated to yield a dark residue which was subjected to flash chromatography (dichloromethane/acetone, 95:5) to afford 4-[3-(4-methylphenyl)-5-imino-4,4-dimethyl-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile, 5b (0.136 g, 0.34 mmol, 17%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08183274B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-40c52929b7174e6a9317a75289f84409 |
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| Source note | uspto-grants-2012_05 |
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