反应详情

1.75 g (9.85 mmol) of N-bromosuccinimide and 10.8 mg (0.006 mmol) of 2,2′-azobis-2-methylpropanenitrile are added to a solution of 2 g (10.95 mmol) of 4-tert-butyl-2-chloro-1-methylbenzene in 10 ml of tetrachloromethane, and the mixtures is stirred under reflux for 4 hours. After cooling, the mixture is concentrated. The residue is purified by flash chromatography on silica gel (mobile phase, cyclohexane). 2.1 g (38% of theory) of the title compound are obtained with a purity of 52%.

1. temperatureunder reflux for 4 hours
2. temperatureAfter cooling
3. concentrationthe mixture is concentrated
4. customThe residue is purified by flash chromatography on silica gel (mobile phase, cyclohexane)