Potassium Carbonate → HCID 57831362, compound

Participants

Reaction Steps

A solution of 438 mg (1.02 mmol) of methyl 4-[(3E)-2-[2-(4-cyanophenyl)ethyl]-4-(2-hydroxyphenyl)but-3-en-1-yl]benzoate in 20 ml of dry acetonitrile is mixed with 382 mg (1.6 mmol) of 2-trifluoromethylbenzyl bromide and 441.3 mg (3.19 mmol) of anhydrous potassium carbonate and heated under reflux for 12 hours. The mixture is then concentrated to dryness. The residue is taken up in ethyl acetate, washed with water and saturated sodium chloride solution and dried over sodium sulfate. The organic phase is concentrated. The resulting crude product is purified by preparative HPLC. 181 mg (0.32 mmol, 31.3% of theory) of a colorless foam are obtained.

Provenance & Evidence