HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(7-cyano-3-hydroxymethylheptyl)benzoate → Methyl 4-(7-cyano-3-formylheptyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(7-cyano-3-hydroxymethylheptyl)benzoate | HCID 57831355 | — |
| Reactant | HCID 178418287 | HCID 178418287 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 4-(7-cyano-3-formylheptyl)benzoate | HCID 57831357 | — |
Reaction Steps
A solution of 2.23 g (7.71 mmol) of methyl 4-(7-cyano-3-hydroxymethylheptyl)benzoate in 100 ml of dichloromethane is mixed with 1.99 g (9.26 mmol) of pyridinium chlorochromate (PCC) and stirred at room temperature for 6 hours. After conversion is complete, the solvent is concentrated to dryness in vacuo. The resulting residue is purified by flash chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 10:1→4:1). 1.50 g (9.09 mmol, 68% of theory) of an oil are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183271B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-233ca1d04b054d20927e10d201128595 |
| Source note | uspto-grants-2012_05 |