Cyclopropylamine → HCID 11504648, compound

Participants

Reaction Conditions

Reaction Steps

Cyclopropylamine (0.082 mL, 1.18 mmol) was added to a solution of Example 57k (0.2 g, 0.39 mmol) in DMF (5 mL) and stirred at 50° C. for 1.5 h. The reaction mixture was concentrated to obtain the title compound which was purified using flash chromatography (silica gel, 1.5% methanol/chloroform). Yield: 0.135 g (71%); 1H NMR (CDCl3): δ 0.49 (m, 2H, CH2), 0.56 (m, 2H, CH2), 1.77 (m, 1H, CH), 2.70 (s, 3H, CH3), 3.01 (t, 2H, CH2), 3.82 (s, 2H, CH2), 3.67 (t, 2H, CH2), 3.92 (s, 3H, OCH3), 4.70 (s, 2H, CH2), 7.36 (s, 1H, Ar), 7.44 (d, 1H, Ar), 8.10 (s, 1H, Ar), 8.46 (d, 1H, Ar); MS: m/e (ES+) 491 (M+1).

Provenance & Evidence