Methanol → HCID 131728495, compound

Participants

Reaction Steps

2-Methoxybenzylamine (1 mL, 2.28 mmol) was added to a solution of Example 102j (0.6 g, 1.25 mmol) in methanol (10 mL), followed by the addition of n-tetrabutylammonium iodide (0.010 g, 0.02 mmol) in an atmosphere of nitrogen and sealed in a pressure reactor vessel at 110° C. for 6 h. It was processed as described in the synthesis of Example 129k to obtain the title compound as a white solid. Yield: 0.250 g, (35.81%); 1H NMR (DMSO-d6): δ 2.60-2.70 (m, 4H, 2CH2), 2.72 (s, 3H, CH3), 3.20-3.30 (m, 4H, 2CH2), 3.70 (s, 2H, CH2), 3.90 (s, 3H, OCH3), 3.95 (s, 3H, CH3), 4.70 (s, 2H, CH2), 6.80 (s, 1H, Ar), 6.90 (s, 1H, Ar), 6.95-7.00 (m, 2H, Ar), 7.30 (t, 1H, Ar), 7.40 (d, 1H, Ar), 8.10 (s, 1H, Ar), 8.50 (s, 1H, Ar); MS: m/e (CI+) 557 (M+1).

Provenance & Evidence