huagongshe.com
HRID1927568

反应详情

EQUATION

反应方程式

HRID 1927568 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CC[C@@H](N)[C@H]1CC[C@@H](C)O1.Cc1ccc(S(=O)(=O)O)cc1
HCID86638630

未命名化合物

结构：CCOc1c(Nc2ccc(Cl)c(S(=O)(=O)N(C)C)c2O)c(=O)c1=O
HCID86641801

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@@H](Nc1c(Nc2ccc(Cl)c(S(=O)(=O)N(C)C)c2O)c(=O)c1=O)[C@H]1CC[C@@H](C)O1
HCID59327354

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

To a stirred solution of 253 mg of 6-chloro-3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-2-hydroxy-N,N-dimethyl-benzenesulfonamide in 5 ml of dry MeCN are added 362 mg of (R)-1-((2R,5R)-5-methyl-tetrahydrofuran-2-yl)-propylamine p-toluenesulfonate salt followed by 94 μl of Et3N at rt under an inert atmosphere of nitrogen. A reaction mixture obtained is heated at reflux for 45 minutes and solvent is evaporatedA residue obtained is purified by flash chromatography on silica eluting with 30-40% EtOAc in iso-hexane. The title compound is obtained. MH+ 472.

WORKUP

后处理

  1. customA reaction mixture obtained
  2. temperatureis heated
  3. temperatureat reflux for 45 minutes
  4. customobtained
  5. customis purified by flash chromatography on silica eluting with 30-40% EtOAc in iso-hexane