HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 2-tert-Butyl-6-chloro-7-methanesulfonyl-benzooxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Tert-butyl-6-chlorobenzoxazole-7-sulfonyl chloride | HCID 23447791 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-tert-Butyl-6-chloro-7-methanesulfonyl-benzooxazole | HCID 67128446 | — |
Reaction Steps
A solution of 204 mg of Na2SO3 and 409 mg of NaHCO3 in 4 ml H2O is heated to 75° and treated portionwise with 0.5 g of 2-tert-butyl-6-chloro-benzooxazole-7-sulfonyl chloride (US 2007/0249672 page 9). A mixture obtained is heated at 75° for 2 hours and 4 ml of EtOH are added followed by 0.11 ml of iodomethane. A mixture obtained is heated at 90° overnight and allowed to cool to rt. A mixture obtained is extracted with 3×30 ml of EtOAc and the combined organic extracts obtained are washed with brine, dried over MgSO4 and solvent is evaporated. The title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183281B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-0bad674880684087a3612d1633aa744b |
| Source note | uspto-grants-2012_05 |