HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 67128629, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Nitrosalicylic acid | HCID 6807 | — |
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67128629 | HCID 67128629 | — |
Reaction Steps
1.19 ml of DIPEA are added to a stirring dispersion of 0.5 g 3-nitrosalicyclic acid and 1.14 g of HATU in 4 ml of DMF at rt under an inert atmosphere of nitrogen. After stirring at it for 1 minute, 0.31 ml of diethylamine in 1 ml of dry DMF are added. After stirring at it for 1 hour, a reaction mixture obtained is added to 50 ml of 1M HCl and extracted with 50 ml EtOAc. Solvent is evaporated and a residue obtained is purified by chromatography on silca eluting with 2:1 iso-hexane/EtOAc. The title compound is obtained. MH+ 239.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183281B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-9005b901e94f40fea1198bf09b3753f9 |
| Source note | uspto-grants-2012_05 |