Nitric Acid → Citrulline Dinitrate

HRID 1927581Notes

Reaction equation

HRID 1927581 reaction equation
[N+:1]([O-:4])([OH:3])=[O:2].[NH2:5][C@H:6]([C:14]([OH:16])=[O:15])[CH2:7][CH2:8][CH2:9][NH:10][C:11]([NH2:13])=[O:12].[N+:17]([O-:20])([OH:19])=[O:18].[NH2:21][C@H:22]([C:30]([OH:32])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27]([NH2:29])=[O:28]>O>[N+:1]([O-:4])([OH:3])=[O:2].[N+:17]([O-:20])([OH:19])=[O:18].[NH2:5][C@H:6]([C:14]([OH:16])=[O:15])[CH2:7][CH2:8][CH2:9][NH:10][C:11]([NH2:13])=[O:12].[N+:1]([O-:4])([OH:3])=[O:2].[N+:1]([O-:4])([OH:3])=[O:2].[N+:1]([O-:4])([OH:3])=[O:2].[NH2:21][C@H:22]([C:30]([OH:32])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27]([NH2:29])=[O:28]

Participants

6

Reactant 3

HCID 944Nitric AcidHCID 9750CitrullineHCID 86628843Citrulline Nitrate

Product 2

HCID 86628841Citrulline DinitrateHCID 86628842Citrulline Trinitrate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Applicants have cost-effectively synthesized Citrulline Nitrate by combining nitric acid and Citrulline, mixing with water, and leaving to crystallize. Further nitratization can take place, yielding Citrulline Dinitrate or Citrulline Trinitrate. An alternative implementation may comprise using Nitrous Acid (HNO2) instead of Nitric Acid (HNO3), thus yielding Citrulline Nitrite. Citrulline Nitrite has the same effects as Citrulline Nitrate, the only difference being that it requires one less step to yield Nitric Oxide (NO—). Mixed salts may also be used, such as in the non-limiting example of Citrulline Nitrate-Orotate.

Workup

  1. customleaving
  2. customto crystallize

Sources & evidence

ORD record
ord-f03f8afc5d1b4358a2166702a382bdb8
Source dataset
uspto-grants-2012_05
Patent number
US08183288B2

Reaction notes

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