HCID 69304112, compound → HCID 16667330, compound

HRID 1927609Notes

Reaction equation

HRID 1927609 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([CH:14]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:15]([NH:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]2)=[C:4]([C:26]#[N:27])[CH:3]=1.C(C1C=C([N+]([O-])=O)C=CC=1N1CC[CH:42]([CH:45]([C:51]2C=CC=C[CH:52]=2)[C:46](NCC)=[O:47])[CH2:41]C1)#N>>[C:26]([C:4]1[CH:3]=[C:2]([NH:1][C:46](=[O:47])[CH:45]([CH2:51][CH3:52])[CH2:42][CH3:41])[CH:7]=[CH:6][C:5]=1[N:8]1[CH2:9][CH2:10][CH:11]([CH:14]([C:15](=[O:16])[NH:17][CH2:18][CH3:19])[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:12][CH2:13]1)#[N:27]

Participants

3

Reactant 2

HCID 69304112HCID 69304112, compoundHCID 69304313HCID 69304313, compound

Product 1

HCID 16667330HCID 16667330, compoundYield 95%

Procedure

2-[1-(4-Amino-2-cyano-phenyl)-piperidin-4-yl]-N-ethyl-2-phenyl-acetamide. 2-[1-(2-Cyano-4-nitro-phenyl)-piperidin-4-yl]-N-ethyl-2-phenyl-acetamide was subjected to reaction conditions similar to those described in Step C to provide the title compound as a yellow powder (600 mg, 95%). MS (ESI): mass calcd. for C22H26N4O, 362.47. m/z found, 363.2 [M+H]+.

Sources & evidence

ORD record
ord-b2a26e8df15e4c6f8c2840e3fde747fc
Source dataset
uspto-grants-2012_05
Patent number
US08183239B2

Reaction notes

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