Hydrochloric Acid → HCID 69303640, compound

Participants

Reaction Conditions

Reaction Steps

A −78° C. solution of 4-(4-cyano-2-fluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (0.27 g, 0.87 mmol) in Et2O (10 mL) was treated with cyclopentylmagnesium chloride (1.5 mL, 2 M). The mixture was allowed to slowly reach rt overnight. The reaction was then cooled to 0° C. and water added (10 mL). The pH of the mixture was adjusted to ˜7 with 1 M HCl and was extracted with Et2O and the solvent removed. Purification on SiO2EtOAc/hexanes) provided 0.19 g of the title compound. MS (ESI): mass calcd. for C21H29FN2O3, 376.47. m/z found, 377.5 [M+H]+.

Provenance & Evidence