HCID 14897375, compound → N,N-Diethyl-2-[4-(2-fluoro-4-formyl-phenyl)-piperazin-1-yl]-2-phenyl-acetamide

HRID 1927624Notes

Reaction equation

HRID 1927624 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)[CH:5]=[O:6].Br[CH:17]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:18]([N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])=[O:19]>>[CH2:23]([N:20]([CH2:21][CH3:22])[C:18](=[O:19])[CH:17]([N:13]1[CH2:14][CH2:15][N:10]([C:9]2[CH:8]=[CH:7][C:4]([CH:5]=[O:6])=[CH:3][C:2]=2[F:1])[CH2:11][CH2:12]1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH3:24]

Participants

3

Reactant 2

HCID 14897375HCID 14897375, compoundHCID 207854653-Fluoro-4-(1-piperazinyl)benzaldehyde

Product 1

HCID 86612370N,N-Diethyl-2-[4-(2-fluoro-4-formyl-phenyl)-piperazin-1-yl]-2-phenyl-acetamideYield 90.1%

Procedure

3-Fluoro-4-piperazin-1-yl-benzaldehyde (0.65 g, 3.1 mmol) was treated with 2-bromo-N,N-diethyl-2-phenyl-acetamide (0.95 g) as described in previous examples to provide 1.11 g of the title compound. MS (ESI): mass calcd. for C21H29FN2O3, 376.47. m/z found, 377.5 [M+H]+.

Sources & evidence

ORD record
ord-c6d2b9ab021d417aba86ba9594c114c7
Source dataset
uspto-grants-2012_05
Patent number
US08183239B2

Reaction notes

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