反应详情

A solution of N,N-diethyl-2-[4-(2-fluoro-4-formyl-phenyl)-piperazin-1-yl]-2-phenyl-acetamide (0.76 g, 1.92 mmol) in ethanol (35 mL) was treated with NaBH4 (0.11 g). After 3 d, the solvent was removed and water (5 mL) and 1 M NaOH were added (˜pH 10). The mixture was extracted with DCM and the solvent removed. Purification on SiO2EtOAc/hexanes) provided 0.73 g of the title compound. MS (ESI): mass calcd. for C23H30FN3O2, 399.5. m/z found, 400.5 [M+H]+.

1. customthe solvent was removed
2. additionwater (5 mL) and 1 M NaOH were added (˜pH 10)
3. extractionThe mixture was extracted with DCM
4. customthe solvent removed
5. customPurification on SiO2EtOAc/hexanes)