Ammonium Hydroxide → HCID 178442427, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(4-bromophenyl)-N-(4,4-dimethyl-2-oxohexyl)propionamide (71.5 g, 202 mmol), ammonium acetate (770 g, 10 mol) and acetic acid (700 mL) was heated at 160° C. for 20 h. Upon cooling, the reaction mixture was poured onto ice (600 mL), and the pH was adjusted to ˜10 with concentrated ammonium hydroxide. The product was extracted with ethyl acetate, and the extracts were dried over sodium sulfate and concentrated to provide 2-[2-(4-bromophenyl)ethyl]-4-(2,2-dimethylbutyl)-1H-imidazole, which was used without purification.

Provenance & Evidence