反应详情

温度

170 °C

A mixture of 2-(1-cyclopropyl-1-methylethyl)malonic acid diethyl ester (5.10 g, 21.2 mmol), lithium chloride (1.79 g, 42.2 mmol), water (0.5 mL) and DMSO (40 mL) was heated at 170° C. for 24 h, and then poured into ice-water. The product was extracted with ethyl acetate (3×200 mL), and the extracts were washed with brine (200 mL), dried over sodium sulfate and concentrated to give 3-cyclopropyl-3-methylbutyric acid ethyl ester, which was used without further purification.

1. extractionThe product was extracted with ethyl acetate (3×200 mL)
2. washthe extracts were washed with brine (200 mL)
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated