4-Methylmorpholine → HCID 59140422, compound

Participants

Reaction Conditions

Reaction Steps

N-Methylmorpholine (54 mL, 0.48 mol) was added to a solution of 4-(2,2-dimethylbutyl)-1H-imidazole (36 g, 0.24 mol) in dimethoxyethane (360 mL). After warming to 40° C., N,N-dimethylsulfamoyl chloride (38 mL, 0.36 mol) was added over 15 min. After stirring at 40° C. for 2 h, N-methylmorpholine (11 mL) and N,N-dimethylsulfamoyl chloride (8 mL) were added. After stirring for additional 2 h, the reaction mixture was cooled and filtered rinsing with ether. The filtrate was extracted with ether and the combined extracts were washed with brine, dried (magnesium sulfate), filtered, concentrated in vacuo. Chromatography over silica gel afforded the title compound.

Provenance & Evidence