HCID 80503395, compound → 2-Amino-1-(3,4-difluorophenyl)ethan-1-ol

HRID 1927678Notes

Reaction equation

HRID 1927678 reaction equation
[N:1]([CH2:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[C:9]([F:14])[CH:8]=1)[OH:6])=[N+]=[N-]>C(O)C.[Pd]>[NH2:1][CH2:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[C:9]([F:14])[CH:8]=1)[OH:6]

Participants

4

Reactant 1

HCID 80503395HCID 80503395, compound

Product 1

HCID 167684452-Amino-1-(3,4-difluorophenyl)ethan-1-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of Pd (10 wt % on carbon; 232 mg, 0.22 mmol) in a solution of afforded 2-azido-1-(3,4-difluorophenyl)ethanol (435 mg, 2.2 mmol) in ethanol (20 mL) was stirred under an atmosphere of hydrogen overnight. The reaction mixture was filtered through Celite, acidified with hydrogen chloride (1 M in diethyl ether) and concentrated in vacuo to afford 2-amino-1-(3,4-difluorophenyl)ethanol, which was used without further purification.

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-34a9ae0f7fe2482daaf6362d3cbbdbff
Source dataset
uspto-grants-2012_05
Patent number
US08183275B2

Reaction notes

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