Piperazin-2-one → HCID 25195646, compound

HRID 1927704Notes

Reaction equation

N1CCNCC1=O.C(O[C:16]1[CH:29]=[C:28](OCC2C=CC=CC=2)[C:27]([C:38]([N:40]2[CH2:48][C:47]3[C:42](=[CH:43][CH:44]=[C:45]([O:49][CH2:50][CH2:51][N:52]4[CH2:57][CH2:56][NH:55][C:54](=[O:58])[CH2:53]4)[CH:46]=3)[CH2:41]2)=[O:39])=[CH:26][C:17]=1[C:18]([N:20]([CH2:22][CH2:23][CH2:24][CH3:25])[CH3:21])=[O:19])C1C=CC=CC=1>>[CH2:22]([N:20]([CH3:21])[C:18](=[O:19])[C:17]1[CH:26]=[C:27]([C:38]([N:40]2[CH2:48][C:47]3[C:42](=[CH:43][CH:44]=[C:45]([O:49][CH2:50][CH2:51][N:52]4[CH2:57][CH2:56][NH:55][C:54](=[O:58])[CH2:53]4)[CH:46]=3)[CH2:41]2)=[O:39])[CH:28]=[CH:29][CH:16]=1)[CH2:23][CH2:24][CH3:25]

Participants

Reactant 2

HCID 231360Piperazin-2-one

HCID 68780414HCID 68780414, compound

Product 1

HCID 25195646HCID 25195646, compound

Procedure

Analogous reaction of “A10a” with piperazin-2-one via 2,4-bisbenzyloxy-N-butyl-N-methyl-5-{5-[2-(3-oxopiperazin-1-yl)ethoxy]-1,3-dihydroisoindole-2-carbonyl}benzamide gives the compound N-butyl-N-methyl-5-{5-[2-(3-oxopiperazin-1-yl)ethoxy]-1,3-dihydroisoindole-2-carbonyl}benzamide (“A15”)

Sources & evidence

ORD record: ord-4d1423e26bed468dbb9ab3c9d4e2a715
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183279B2

Reaction notes

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