1,4-Dioxane hydrochloride → HCID 66879498, compound

HRID 1927800Notes

Reaction equation

HRID 1927800 reaction equation
C(OC([N:8]1[C@H:12]([C:13]([NH2:15])=[O:14])[CH2:11][S:10][CH2:9]1)=O)(C)(C)C.[ClH:16].O1CCOCC1>>[ClH:16].[S:10]1[CH2:11][C@@H:12]([C:13]([NH2:15])=[O:14])[NH:8][CH2:9]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 51340398HCID 51340398, compound

Product 1

HCID 66879498HCID 66879498, compoundYield 99%

Procedure

(4R)-3-(tert-Butyloxycarbonyl)thiazolidine-4-carboxamide (8.6 g, 37.1 mmol) was dissolved in 4M HCl/dioxan (50 ml). After 1 h at room temperature the solvent was evaporated in vacuo to give a white solid identified as the title compound (6.2 g, 36.8 mmol, 99%).

Workup

  1. customAfter 1 h at room temperature the solvent was evaporated in vacuo
  2. customto give a white solid

Sources & evidence

ORD record
ord-17174d8349a4427c9777b79fa6c59211
Source dataset
uspto-grants-2012_05
Patent number
US08183280B2

Reaction notes

Loading…