HCID 68710350, compound → HCID 61173950, compound

HRID 1927805Notes

Reaction equation

HRID 1927805 reaction equation
C([O:5][C:6](=[O:23])[C@@H:7]([NH:12][C:13](=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:20][CH3:21])[CH:8]([CH3:11])[CH2:9][CH3:10])(C)(C)C>FC(F)(F)C(O)=O.C(Cl)Cl>[CH3:21][O:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:13]([NH:12][C@@H:7]([CH:8]([CH3:11])[CH2:9][CH3:10])[C:6]([OH:23])=[O:5])=[O:22]

Participants

3

Reactant 1

HCID 68710350HCID 68710350, compound

Product 1

HCID 61173950HCID 61173950, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

(2S)-2-(2-Methoxybenzoylamino)-3-methylpentanoic acid tertbutyl ester (341 mg, 1.06 mmol) was dissolved in trifluoroacetic acid/CH2Cl2 (1:1, 10 ml). After 2 h at room temperature the solvent was removed in vacuo and the residue was purified by flash chromatography (eluant: 1% acetic acid, 2% methanol, 97% chloroform) to give a colourless oil identified as the title compound (242 mg, 0.91 mmol, 86%).

Workup

  1. customAfter 2 h at room temperature the solvent was removed in vacuo
  2. customthe residue was purified by flash chromatography (eluant: 1% acetic acid, 2% methanol, 97% chloroform)
  3. customto give a colourless oil

Sources & evidence

ORD record
ord-ba45ac0bcb4942a781a593828eba61a5
Source dataset
uspto-grants-2012_05
Patent number
US08183280B2

Reaction notes

Loading…