HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-6-trifluoromethyl-4-(4-trifluoromethylphenyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-trifluoromethyl-4-(4-trifluoromethylphenyl)-1H-pyridin-2-one | HCID 57468638 | — |
| Product | 2-Chloro-6-trifluoromethyl-4-(4-trifluoromethylphenyl)-pyridine | HCID 57468635 | — |
Reaction Steps
The title compound was prepared from 6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (23.7 g, 77 mmol) and phosphoryl chloride (35.2 mL, 386 mmol) according to the general procedure Ia to d preparation of chlorides. Obtained as an off-white solid (16.5 g, 66%). MS (ISP) 326.1 [(M+H)+] and 328 [(M+2+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-c172e3353df64790a6fd039c91634cf5 |
| Source note | uspto-grants-2012_05 |