HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-4-(4-chloro-3-methyl-phenyl)-6-methyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-(4-Chloro-3-methyl-phenyl)-6-methyl-1h-pyrimidin-2-one | HCID 57468671 | — |
| Product | 2-Chloro-4-(4-chloro-3-methyl-phenyl)-6-methyl-pyrimidine | HCID 57468670 | — |
Reaction Steps
The title compound was prepared from 4-(4-chloro-3-methyl-phenyl)-6-methyl-1H-pyrimidin-2-one (9.78 g, 41.7 mmol) and phosphoroxychloride (98 mL) according to the general procedure I. Obtained as an off-white solid (7.38 g, 70%). MS (ISP) 253.1 [(M+H)+]; mp 131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-e53d5239eb7d412199a93992d94180c9 |
| Source note | uspto-grants-2012_05 |