2-Chloro-4-iodopyridine → HCID 57468734, compound

HRID 1927870Notes

Reaction equation

HRID 1927870 reaction equation
I[C:2]1[N:7]=[C:6]([CH:8]([F:10])[F:9])[CH:5]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[N:3]=1.[Cl:21][C:22]1[CH:27]=[C:26](I)[CH:25]=[CH:24][N:23]=1>>[Cl:21][C:22]1[CH:27]=[C:26]([C:2]2[N:7]=[C:6]([CH:8]([F:10])[F:9])[CH:5]=[C:4]([C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=3)[N:3]=2)[CH:25]=[CH:24][N:23]=1

Participants

3

Reactant 2

HCID 15165112-Chloro-4-iodopyridineHCID 57468610HCID 57468610, compound

Product 1

HCID 57468734HCID 57468734, compound

Procedure

The title compound was prepared from 2-iodo-4-difluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (example A.9) (0.43 g, 1.07 mmol) and commercially available 2-chloro-4-iodo-pyridine [CAS No. 153034-86-7] (263 mg, 1.1 mmol) according to the general procedure IVc protocol a. Obtained as an off-white solid (0.20 g, 48%). MS (ISP) 386.0 [(M+H)+]; mp 143.5° C.

Sources & evidence

ORD record
ord-c91f3664d0e047729ed207e417ac930d
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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