2-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine → HCID 57468737, compound

HRID 1927873Notes

Reaction equation

HRID 1927873 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[Br:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1>>[Br:19][C:20]1[N:21]=[CH:22][N:23]([C:2]2[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)[N:3]=2)[CH:24]=1

Participants

3

Reactant 2

HCID 574686142-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidineHCID 178418934HCID 178418934, compound

Product 1

HCID 57468737HCID 57468737, compound

Procedure

The title compound was prepared from 2-chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (example A.12) (2.73 g, 10.0 mmol) and commercially available 4-bromo-imidazole (2.21 g, 15.0 mmol) according to the general procedure IVa. Obtained as a light brown solid (3.20 g, 84%). MS (ISP) 383.0 [(M+H)+]; mp 166-168° C.

Sources & evidence

ORD record
ord-cdf2897f1a02456dbc45f7c452a0f4f0
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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