HCID 57468618, compound → HCID 57468740, compound

HRID 1927876Notes

Reaction equation

HRID 1927876 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)[N:6]=1)(=O)=O.[I:25][C:26]1[N:27]=[CH:28][NH:29][CH:30]=1>>[I:25][C:26]1[N:27]=[CH:28][N:29]([C:5]2[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=3)[N:6]=2)[CH:30]=1

Participants

3

Reactant 2

HCID 57468618HCID 57468618, compoundHCID 178506559HCID 178506559, compound

Product 1

HCID 57468740HCID 57468740, compound

Procedure

The title compound was prepared 2-methanesulfonyl-4-trifluoromethyl-6-(3-trifluoromethyl-phenyl)-pyrimidine (example A.15) (1.1 g, 3 mmol) and commercially available 4-iodo-imidazole (0.70 g, 4 mmol) according to the general procedure IVa. Obtained as a white solid (0.96 g, 66%). MS (ISP) 485.2 [(M+H)+].

Sources & evidence

ORD record
ord-cff21b50876b4d9e8fb266306472b481
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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