(3-Bromophenyl)boronic acid → 2-(3-Bromo-phenyl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine

HRID 1927880Notes

Reaction equation

HRID 1927880 reaction equation
Br[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[N:3]=1.[Br:22][C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][CH:28]=1>>[Br:22][C:23]1[CH:28]=[C:27]([C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:5]=[C:4]([C:12]3[CH:13]=[CH:14][C:15]([C:18]([F:19])([F:21])[F:20])=[CH:16][CH:17]=3)[N:3]=2)[CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 57468624HCID 57468624, compound

Product 1

HCID 574687442-(3-Bromo-phenyl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine

Procedure

The title compound was prepared from 2-bromo-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine (example A.19) (3.0 g, 8 mmol) and commercially available 3-bromo-benzene-boronic acid (1.954 g, 10 mmol) according to the general procedure IVb. Obtained as an orange oil (3.28 g, 91%). MS (ISP) 446.0 [(M+H)+] and 448.0 [(M+2+H)+].

Sources & evidence

ORD record
ord-35b59f533801485c9d20ad0d0d9b0541
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

Loading…