HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dibromopyridine → 6'-Bromo-6-methyl-4-(4-trifluoromethylphenyl)-[2,2']bipyridinyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dibromopyridine | HCID 12274 | — |
| Reactant | 2-Iodo-6-methyl-4-(4-trifluoromethyl-phenyl)pyridine | HCID 57468645 | — |
| Catalyst | HCID 178461728 | HCID 178461728 | — |
| Product | 6'-Bromo-6-methyl-4-(4-trifluoromethylphenyl)-[2,2']bipyridinyl | HCID 86615440 | — |
Reaction Steps
The title compound was prepared from 2-iodo-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine (example A.31) (1.09 g, 3.0 mmol), i-PrMgBr/ZnBr2 and commercially available 2,6-dibromopyridine (2.13 g, 9 mmol) according to the general procedure IVc protocol b. Obtained as a light yellow solid (0.826 g, 70%). MS (ISP) 393.0 [(M+H)+] and 394.8 [(M+2+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-03326184e05740f0871c94e7fda9326b |
| Source note | uspto-grants-2012_05 |