HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-iodopyridine → 2'-Chloro-6-methyl-4-(4-trifluoromethylphenyl)-[2,4']bipyridinyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-iodopyridine | HCID 1516511 | — |
| Reactant | Trifluoro-methanesulfonic acid 6-methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl ester | HCID 57468647 | — |
| Catalyst | HCID 178461731 | HCID 178461731 | — |
| Product | 2'-Chloro-6-methyl-4-(4-trifluoromethylphenyl)-[2,4']bipyridinyl | HCID 86615442 | — |
Reaction Steps
The title compound was prepared from trifluoro-methanesulfonic acid 6-methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl ester (example A.32) (3.0 g, 7.8 mmol), commercially available 2-chloro-4-iodo-pyridine [CAS No. 153034-86-7] (1.92 g, 8.0 mmol) and i-PrMgCl/ZnCl2 according to the general procedure IVc protocol a. Obtained as a white solid (1.50 g, 55%). MS (ISP) 349.2 [(M+H)+] and 351 [(M+2+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-ede0772aabdd47f7aaab22c5b08f5f12 |
| Source note | uspto-grants-2012_05 |