(3-Bromophenyl)boronic acid → HCID 57468752, compound

HRID 1927893Notes

Reaction equation

HRID 1927893 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[C:10]([O:18][CH2:19][CH3:20])[CH:9]=2)[CH:5]=[C:4]([C:21]([F:24])([F:23])[F:22])[N:3]=1.[Br:25][C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][CH:31]=1>>[Br:25][C:26]1[CH:31]=[C:30]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[C:10]([O:18][CH2:19][CH3:20])[CH:9]=3)[CH:5]=[C:4]([C:21]([F:24])([F:23])[F:22])[N:3]=2)[CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 57468611HCID 57468611, compound

Product 1

HCID 57468752HCID 57468752, compound

Procedure

The title compound was prepared from 2-chloro-4-(3-ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine (example A.10) (0.25 g, 0.67 mmol) and commercially available 3-bromo-benzene-boronic acid (0.17 g, 0.85 mmol) according to the general procedure IVb. Obtained as a light yellow solid (0.32 g, 97%). MS (EI) 492.0 [(M)+]; mp 108° C.

Sources & evidence

ORD record
ord-7bd8b5aad1b94dc5b64888ba0832893d
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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