HCID 57468605, compound → HCID 57468753, compound

HRID 1927894Notes

Reaction equation

HRID 1927894 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[C:10]([F:18])[CH:9]=2)[CH:5]=[C:4]([C:19]([F:22])([F:21])[F:20])[N:3]=1.[Br:23][C:24]1[N:25]=[CH:26][NH:27][CH:28]=1>>[Br:23][C:24]1[N:25]=[CH:26][N:27]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[C:10]([F:18])[CH:9]=3)[CH:5]=[C:4]([C:19]([F:22])([F:21])[F:20])[N:3]=2)[CH:28]=1

Participants

3

Reactant 2

HCID 57468605HCID 57468605, compoundHCID 178418934HCID 178418934, compound

Product 1

HCID 57468753HCID 57468753, compound

Procedure

The title compound was prepared from 2-chloro-4-(3-fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine (example A.6) (0.50 g, 1.45 mmol) and commercially available 4-bromo-imidazole (0.32 g, 2.18 mmol) according to the general procedure IVa. Obtained as a white solid (0.34 g, 51%). MS (EI) 455.1 [(M)+]; mp 164.5° C.

Sources & evidence

ORD record
ord-a98fd39e0fca4cf18cca6333337940c3
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

Loading…