HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloropyridine-4-boronic acid → 4-(4-Chloro-phenyl)-2-(2-chloro-pyridin-4-yl)-6-methyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloropyridine-4-boronic acid | HCID 5151595 | — |
| Reactant | 2-Chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidine | HCID 20225570 | — |
| Product | 4-(4-Chloro-phenyl)-2-(2-chloro-pyridin-4-yl)-6-methyl-pyrimidine | HCID 57468762 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidine (example A.11) (0.24 g, 1.0 mmol) and commercially available 2-chloro-pyridine-4-boronic acid (0.21 g, 1.3 mmol) according to the general procedure IVb. Obtained as a light yellow solid (0.23 g, 73%). MS (ISP) 316.1 [(M+H)+]; mp 175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-c5f61532f79342dca3b4ff22a1df6277 |
| Source note | uspto-grants-2012_05 |