HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine → 2-(3-Chloro-[1,2,4]triazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine | HCID 57468614 | — |
| Reactant | HCID 178478410 | HCID 178478410 | — |
| Product | 2-(3-Chloro-[1,2,4]triazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine | HCID 57468779 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (example A.12) (0.4 g, 1.47 mmol) and commercially available 3-chloro-1H-[1,2,4]triazole (0.22 g, 2.17 mmol) according to the general procedure IVa. Obtained as a yellow solid (0.36 g, 72%). MS (ISP) 340.0 [(M+H)+]; mp 137.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-43ec60c56fc0419cafadc9a30719efb0 |
| Source note | uspto-grants-2012_05 |