Thiophene, 2,4-dibromo- → 2-(4-Bromo-thiophen-2-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

HRID 1927943Notes

Reaction equation

HRID 1927943 reaction equation
I[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:5]=[C:4]([CH3:18])[N:3]=1.Br[C:20]1[S:21][CH:22]=[C:23]([Br:25])[CH:24]=1>>[Br:25][C:23]1[CH:24]=[C:20]([C:2]2[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)[CH:5]=[C:4]([CH3:18])[N:3]=2)[S:21][CH:22]=1

Participants

3

Reactant 2

HCID 2724560Thiophene, 2,4-dibromo-HCID 574686452-Iodo-6-methyl-4-(4-trifluoromethyl-phenyl)pyridine

Product 1

HCID 574688022-(4-Bromo-thiophen-2-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

Procedure

The title compound was prepared from 2-iodo-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine (example A.31) (4.0 g, 9.36 mmol) and commercially available 2,4-dibromothiophene (2.518 g, 10.41 mmol) according to the general procedure IVc protocol b. Obtained as a white solid (2.12 g, 54%). MS (ISP) 398.0 [(M+H)+] and 400.0 [(M+2+H)+].

Sources & evidence

ORD record
ord-70958e38f79e4f66971a1a58145fb0e4
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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