(3-Bromophenyl)boronic acid → HCID 57468804, compound

HRID 1927944Notes

Reaction equation

HRID 1927944 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=[C:4](OS(C(F)(F)F)(=O)=O)[CH:3]=1.[Br:26][C:27]1[CH:28]=[C:29](B(O)O)[CH:30]=[CH:31][CH:32]=1>>[Br:26][C:27]1[CH:32]=[C:31]([C:4]2[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)[N:5]=2)[CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 57468680HCID 57468680, compound

Product 1

HCID 57468804HCID 57468804, compound

Procedure

The title compound was prepared from trifluoro-methanesulfonic acid 4-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl ester (example A.55) (1.6 g, 4.15 mmol) and commercially available 3-bromobenzeneboronic acid (0.751 g, 3.74 mmol) according to the general procedure Iba. Obtained as a light yellow oil (1.39 g, 85%). MS (ISP) 392.0 [(M+H)+] and 394.1 [(M+2+H)+].

Sources & evidence

ORD record
ord-1a92711c8b5e468d9506b7068b643dca
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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