(3-Bromophenyl)boronic acid → HCID 68689698, compound

HRID 1927945Notes

Reaction equation

HRID 1927945 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:15]=[C:14]([CH3:16])[N:13]=[C:12](OS(C(F)(F)F)(=O)=O)[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1.[Br:25][C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][CH:31]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:15]=[C:14]([CH3:16])[N:13]=[C:12]([C:30]4[CH:29]=[CH:28][CH:27]=[C:26]([Br:25])[CH:31]=4)[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 86615435HCID 86615435, compound

Product 1

HCID 68689698HCID 68689698, compound

Procedure

The title compound was prepared from trifluoro-methanesulfonic acid 4-benzo[1,3]dioxol-5-yl-6-methyl-pyridin-2-yl ester (example A.56) (1.1 g, 3.04 mmol) and commercially available 3-bromobenzeneboronic acid (0.611 g, 3.04 mmol) according to the general procedure IVb. Obtained as a colorless gum (0.44 g, 39%). MS (ISP) 368.0 [(M+H)+] and 370.0 [(M+2+H)+].

Sources & evidence

ORD record
ord-32572a79aefc41598194616618e1b26f
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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