(3-Bromophenyl)boronic acid → 2-(3-Bromo-phenyl)-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine

HRID 1927954Notes

Reaction equation

HRID 1927954 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[C:10]([F:15])[CH:9]=2)[CH:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[N:3]=1.[Br:20][C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][CH:26]=1>>[Br:20][C:21]1[CH:26]=[C:25]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([F:14])=[C:10]([F:15])[CH:9]=3)[CH:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[N:3]=2)[CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 574686682-Chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine

Product 1

HCID 574688102-(3-Bromo-phenyl)-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine (example A.46) (1.50 g, 5.1 mmol) and commercially available 3-bromo-benzene-boronic acid (1.23 g, 6.12 mmol) according to the general procedure IVb. Obtained as a white solid (1.23 g, 58%). MS (EI) 416.0 [(M)+]; mp 103° C.

Sources & evidence

ORD record
ord-4d3f1a780ce64eecb432c96ed82faf96
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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