2-Chloropyridine-4-boronic acid → HCID 57468812, compound

HRID 1927956Notes

Reaction equation

HRID 1927956 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[N:3]=1.[Cl:19][C:20]1[CH:25]=[C:24](B(O)O)[CH:23]=[CH:22][N:21]=1>>[Cl:19][C:20]1[CH:25]=[C:24]([C:2]2[N:3]=[C:4]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=2)[CH:23]=[CH:22][N:21]=1

Participants

3

Reactant 2

HCID 51515952-Chloropyridine-4-boronic acidHCID 57468667HCID 57468667, compound

Product 1

HCID 57468812HCID 57468812, compound

Procedure

The title compound was prepared from 2-chloro-6-(4-fluoro-phenyl)-4-trifluoromethyl-pyrimidine (example A.45) (1.5 g, 5.42 mmol) and commercially available 2-chloro-pyridine-4-boronic acid (1.02 g, 6.48 mmol) according to the general procedure IVb. Obtained as a light brown solid (0.49 g, 26%). MS (ISP) 354.2 [(M+H)+]; mp 138.5° C.

Sources & evidence

ORD record
ord-9d3302ea85d64f0e97c44118b946a283
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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