(3-Bromophenyl)boronic acid → HCID 57468815, compound

HRID 1927959Notes

Reaction equation

HRID 1927959 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:18])(C(F)(F)F)[CH2:10][C:9]=2[Cl:19])[CH:5]=[C:4]([C:20]([F:23])([F:22])[F:21])[N:3]=1.[Br:24][C:25]1[CH:26]=[C:27](B(O)O)[CH:28]=[CH:29][CH:30]=1>>[Br:24][C:25]1[CH:30]=[C:29]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:18])=[CH:10][C:9]=3[Cl:19])[CH:5]=[C:4]([C:20]([F:21])([F:22])[F:23])[N:3]=2)[CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 86615449HCID 86615449, compound

Product 1

HCID 57468815HCID 57468815, compound

Procedure

The title compound was prepared from 2-chloro-4-(2,4-dichloro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine (example A.61) (1.50 g, 4.58 mmol) and commercially available 3-bromo-benzene-boronic acid (1.01 g, 5.03 mmol) according to the general procedure IVb. Obtained as a white solid (1.26 g, 61%). MS (EI) 447.9 [(M)+]; mp 124.5° C.

Sources & evidence

ORD record
ord-7da2d2d4e6d0410785475de0e4efde75
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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