HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1927963Generated: November 2, 2026
N-Methyldiethanolamine → 2-(5-Bromo-pyridin-3-yl)-6-methyl-[1,3,6,2]dioxazaborocane
https://huagongshe.com/reaction/1927963
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-Methyldiethanolamine | HCID 7767 | — |
| Reactant | 5-Bromopyridine-3-boronic acid | HCID 3814811 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(5-Bromo-pyridin-3-yl)-6-methyl-[1,3,6,2]dioxazaborocane | HCID 57468819 | 100% |
Reaction Steps
Step 1) A mixture of 3-bromopyridine-5-boronic acid [CAS-no. 452972-09-7] (10 g, 50 mmol) and N-methyldiethanolamine (5.9 g, 50 mmol) in toluene (50 mL) was stirred at 23° C. for 24 h, then totally evaporated, triturated with heptane to give 2-(5-bromo-pyridin-3-yl)-6-methyl-[1,3,6,2]dioxazaborocane (14.1 g, 100%) as an off-white solid. MS (ISP) 285.0 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08183262B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-88660360a4d744fb9b354a81d08b204b |
|---|
| Source note | uspto-grants-2012_05 |
|---|
