HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 4-(4-Chloro-phenyl)-2-imidazol-1-yl-6-trifluoromethyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | HCID 4504275 | HCID 4504275 | — |
| Product | 4-(4-Chloro-phenyl)-2-imidazol-1-yl-6-trifluoromethyl-pyrimidine | HCID 3415095 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-6-trifluoromethyl-pyrimidine (example A.1) (0.15 g, 0.5 mmol) and commercially available imidazole (0.034 g, 0.5 mmol) according to the general procedure IVa. Obtained as an off-white solid (0.063 g, 39%). MS (EI) 324.1 [(M)+]; mp 175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-1059e7eb7ec642b8a18fc0d4d83287f8 |
| Source note | uspto-grants-2012_05 |