2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine → HCID 24760144, compound

HRID 1927995Notes

Reaction equation

HRID 1927995 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:5]=[C:4]([C:18]([F:21])([F:20])[F:19])[N:3]=1.[NH:22]1[CH:26]=[C:25]([C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)[N:24]=[CH:23]1>>[N:29]1[CH:30]=[CH:31][CH:32]=[C:27]([C:25]2[N:24]=[CH:23][N:22]([C:2]3[N:3]=[C:4]([C:18]([F:21])([F:20])[F:19])[CH:5]=[C:6]([C:8]4[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=4)[N:7]=3)[CH:26]=2)[CH:28]=1

Participants

3

Reactant 2

HCID 574685992-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidineHCID 178420772HCID 178420772, compound

Product 1

HCID 24760144HCID 24760144, compound

Procedure

The title compound was prepared from 2-chloro-4-(4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine (example A.2) (0.16 g, 0.5 mmol) and commercially available 3-(1H-imidazol-4-yl)-pyridine [CAS-No. 51746-85-1] (0.073 g, 0.5 mmol) according to the general procedure IVa. Obtained as a light brown solid (0.11 g, 49%). MS (ISP) 436.1 [(M)+]; mp 200.5° C.

Sources & evidence

ORD record
ord-87fffe8d31dc4aaa8772466c7f1accff
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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