HCID 4504275, compound → 4-(4-Chloro-phenyl)-2-(4-pyridin-3-yl-imidazol-1-yl)-6-trifluoromethyl-pyrimidine

HRID 1927997Notes

Reaction equation

HRID 1927997 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:5]=[C:4]([C:15]([F:18])([F:17])[F:16])[N:3]=1.[NH:19]1[CH:23]=[C:22]([C:24]2[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=2)[N:21]=[CH:20]1>>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2[CH:5]=[C:4]([C:15]([F:18])([F:17])[F:16])[N:3]=[C:2]([N:19]3[CH:23]=[C:22]([C:24]4[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=4)[N:21]=[CH:20]3)[N:7]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 4504275HCID 4504275, compoundHCID 178420772HCID 178420772, compound

Product 1

HCID 247601454-(4-Chloro-phenyl)-2-(4-pyridin-3-yl-imidazol-1-yl)-6-trifluoromethyl-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-6-trifluoromethyl-pyrimidine (example A.1) (0.15 g, 0.5 mmol) and commercially available 3-(1H-imidazol-4-yl)-pyridine [CAS-No. 51746-85-1] (0.073 g, 0.5 mmol) according to the general procedure IVa. Obtained as a light brown solid (0.09 g, 45%). MS (EI) 401.1 [(M)+]; mp 228° C.

Sources & evidence

ORD record
ord-6d18848be07c4d0d8fe3e8abf38a4425
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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